Stadium: Mihalik-Thompson Stadium Round: 1
| NCAAF | 2021/09/02 22:00 | Wayne State Warriors Football v Slippery Rock | W | 21-24 |
| NCAAF | 2019/09/05 22:00 | Wayne State Warriors Football v Slippery Rock | W | 37-62 |
| NCAAF | 2021/11/20 17:00 | Notre Dame Falcons v Slippery Rock | L | 33-25 |
| NCAAF | 2021/11/06 17:00 | Slippery Rock v California Vulcans | W | 38-26 |
| NCAAF | 2021/10/30 16:00 | Gannon University Golden Knights v Slippery Rock | W | 21-63 |
| NCAAF | 2021/10/23 16:00 | Mercyhurst v Slippery Rock | W | 17-20 |
| NCAAF | 2021/10/16 17:00 | Slippery Rock v Iup Crimson Hawks | L | 21-48 |
| NCAAF | 2021/10/09 18:00 | Edinboro v Slippery Rock | W | 13-49 |
| NCAAF | 2021/10/02 22:00 | Slippery Rock v Clarion Golden Eagles | W | 75-0 |
| NCAAF | 2021/09/25 22:00 | Seton Hill Griffins v Slippery Rock | W | 17-41 |
| NCAAF | 2021/11/13 18:00 | Ferris State v Wayne State Warriors Football | L | 35-13 |
| NCAAF | 2021/11/06 17:00 | Wayne State Warriors Football v Grand Valley State | L | 13-62 |
| NCAAF | 2021/10/30 22:00 | Wayne State Warriors Football v Northwood Timberwolves | W | 56-21 |
| NCAAF | 2021/10/23 19:00 | Saginaw Valley State Cardinals v Wayne State Warriors Football | L | 41-25 |
| NCAAF | 2021/10/16 16:00 | Davenport Panthers v Wayne State Warriors Football | W | 3-16 |
| NCAAF | 2021/10/09 22:00 | Wayne State Warriors Football v Michigan Technological University Huskies | L | 27-30 |
| NCAAF | 2021/10/02 20:00 | Northern Michigan Wildcats v Wayne State Warriors Football | L | 26-19 |
| NCAAF | 2021/09/25 22:00 | Wayne State Warriors Football v Saginaw Valley State Cardinals | L | 21-41 |