Stadium: Charles L. Currier Memorial Field Round: 1
| NCAAF | 2021/09/04 17:00 | Castleton Spartans v Plymouth State Panthers | L | 13-0 |
| NCAAF | 2019/09/07 17:00 | Castleton Spartans v Plymouth State Panthers | W | 17-23 |
| NCAAF | 2018/09/01 17:00 | Castleton Spartans v Plymouth State Panthers | W | 0-38 |
| NCAAF | 2021/11/13 17:00 | Umass Dartmouth Corsairs v Plymouth State Panthers | L | 28-7 |
| NCAAF | 2021/11/06 17:00 | Plymouth State Panthers v Massachusetts Maritime Buccaneers | W | 27-7 |
| NCAAF | 2021/10/30 16:00 | Westfield State Owls v Plymouth State Panthers | W | 7-17 |
| NCAAF | 2021/10/23 17:00 | Plymouth State Panthers v Worcester State Lancers | W | 42-14 |
| NCAAF | 2021/10/16 16:00 | Plymouth State Panthers v Fitchburg State Falcons | W | 36-0 |
| NCAAF | 2021/10/09 19:00 | Western Connecticut Colonials v Plymouth State Panthers | W | 13-16 |
| NCAAF | 2021/10/02 17:00 | Plymouth State Panthers v Framingham State Rams | L | 0-33 |
| NCAAF | 2021/09/18 19:00 | Bridgewater State Bears v Plymouth State Panthers | L | 27-24 |
| NCAAF | 2021/11/13 17:00 | Castleton Spartans v Gallaudet Bison | W | 31-30 |
| NCAAF | 2021/11/06 16:00 | Alfred State Pioneers v Castleton Spartans | L | 35-24 |
| NCAAF | 2021/10/30 18:00 | Castleton Spartans v Anna Maria Amcats | W | 38-31 |
| NCAAF | 2021/10/23 16:00 | Castleton Spartans v Keystone Giants | W | 41-0 |
| NCAAF | 2021/10/09 16:00 | Dean Bulldogs v Castleton Spartans | W | 13-21 |
| NCAAF | 2021/10/02 16:00 | Suny Maritime Privateers v Castleton Spartans | L | 19-16 |
| NCAAF | 2021/09/25 20:00 | St Lawrence Saints v Castleton Spartans | L | 55-3 |
| NCAAF | 2021/09/18 19:00 | Castleton Spartans v Norwich Cadets | L | 12-28 |