Stadium: Trinity Football Stadium Round: 1
| NCAAF | 2021/11/20 18:00 | Mary Hardin Baylor v Trinity Tigers | L | 13-3 |
| NCAAF | 2021/11/13 20:00 | Trinity Tigers v Rhodes Lynx | W | 55-21 |
| NCAAF | 2021/11/06 17:00 | Birmingham Southern Panthers v Trinity Tigers | W | 27-28 |
| NCAAF | 2021/10/30 17:00 | Trinity Tigers v Hendrix Warriors | W | 62-13 |
| NCAAF | 2021/10/23 17:00 | Sewanee Tigers v Trinity Tigers | W | 7-66 |
| NCAAF | 2021/10/16 18:00 | Trinity Tigers v Millsaps Majors | W | 46-0 |
| NCAAF | 2021/10/09 18:30 | Trinity Tigers v Centre Colonels | W | 27-7 |
| NCAAF | 2021/10/02 22:00 | Berry Vikings v Trinity Tigers | W | 6-27 |
| NCAAF | 2021/11/13 19:00 | Southwestern Pirates v Sul Ross State Lobos | L | 49-15 |
| NCAAF | 2021/11/06 17:00 | Sul Ross State Lobos v East Texas Baptist Tigers | L | 28-31 |
| NCAAF | 2021/10/30 18:00 | Mcmurry Warhawks v Sul Ross State Lobos | W | 11-24 |
| NCAAF | 2021/10/23 18:00 | Sul Ross State Lobos v Mary Hardin Baylor | L | 14-72 |
| NCAAF | 2021/10/16 17:00 | Belhaven Blazers v Sul Ross State Lobos | L | 44-0 |
| NCAAF | 2021/10/09 21:00 | Sul Ross State Lobos v North American Stallions | L | 37-44 |
| NCAAF | 2021/10/02 20:30 | Howard Payne Yellow Jackets v Sul Ross State Lobos | L | 73-30 |
| NCAAF | 2021/09/25 23:00 | Sul Ross State Lobos v Texas Lutheran Bulldogs | W | 12-10 |