Stadium: Holmgren Athletic Complex Round: 1
| NCAAF | 2021/11/13 18:00 | North Central Illinois v North Park Vikings | L | 84-6 |
| NCAAF | 2021/11/06 18:00 | North Park Vikings v Millikin Big Blue | L | 0-21 |
| NCAAF | 2021/10/30 18:00 | Illinois Wesleyan Titans v North Park Vikings | L | 56-6 |
| NCAAF | 2021/10/23 18:00 | North Park Vikings v Elmhurst Bluejays | W | 45-3 |
| NCAAF | 2021/10/16 18:00 | Carthage Red Men v North Park Vikings | W | 30-33 |
| NCAAF | 2021/10/09 19:00 | North Park Vikings v Carroll Pioneers | L | 26-34 |
| NCAAF | 2021/10/02 18:00 | Augustana Augie v North Park Vikings | L | 17-14 |
| NCAAF | 2021/09/25 18:00 | North Park Vikings v Wheaton Thunder | L | 27-58 |
| NCAAF | 2021/11/13 18:30 | Manchester Spartans v Anderson Ravens | W | 3-0 |
| NCAAF | 2021/11/06 17:30 | Bluffton Beavers v Manchester Spartans | L | 31-7 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | L | 33-0 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2021/10/16 17:30 | Mount St. Joseph Lions v Manchester Spartans | L | 28-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | W | 22-0 |
| NCAAF | 2021/10/02 17:30 | Franklin College Grizzlies v Manchester Spartans | W | 24-27 |
| NCAAF | 2021/09/18 17:00 | Olivet Comets v Manchester Spartans | L | 59-7 |