Stadium: Hollett Little Giant Stadium Round: 1
| NCAAF | 2021/11/13 18:07 | Wabash Little Giants v Depauw Tigers | W | 42-35 |
| NCAAF | 2021/11/06 17:00 | Wabash Little Giants v Wittenberg Tigers | L | 14-35 |
| NCAAF | 2021/10/30 17:00 | Kenyon Lords v Wabash Little Giants | W | 34-59 |
| NCAAF | 2021/10/23 17:00 | Ohio Wesleyan Battling Bishops v Wabash Little Giants | L | 35-28 |
| NCAAF | 2021/10/16 17:00 | Wabash Little Giants v Wooster Scots | L | 41-44 |
| NCAAF | 2021/10/09 18:00 | Wabash Little Giants v Oberlin Yeomen | W | 49-20 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | W | 38-39 |
| NCAAF | 2021/09/18 18:00 | Wabash Little Giants v Allegheny Gators | W | 36-28 |
| NCAAF | 2021/11/13 18:00 | Randolph Macon Yellow Jackets v Hampden Sydney Tigers | L | 37-14 |
| NCAAF | 2021/11/06 17:00 | Hampden Sydney Tigers v Bridgewater Eagles | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | The Apprentice School Builders v Hampden Sydney Tigers | W | 21-38 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | W | 42-28 |
| NCAAF | 2021/10/16 17:00 | Emory And Henry Wasps v Hampden Sydney Tigers | L | 37-13 |
| NCAAF | 2021/10/02 17:00 | Hampden Sydney Tigers v Washington And Lee Generals | L | 30-32 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | W | 27-28 |
| NCAAF | 2021/09/18 17:00 | Hampden Sydney Tigers v Shenandoah Hornets | W | 28-7 |