| NCAAF | 2021/11/06 17:00 | Suny Maritime Privateers v Keystone Giants | L | 24-21 |
| NCAAF | 2021/10/30 18:00 | Keystone Giants v Alfred State Pioneers | L | 7-38 |
| NCAAF | 2021/10/23 16:00 | Castleton Spartans v Keystone Giants | L | 41-0 |
| NCAAF | 2021/10/16 16:00 | Keystone Giants v Dean Bulldogs | L | 36-39 |
| NCAAF | 2021/10/09 16:00 | Gallaudet Bison v Keystone Giants | L | 34-14 |
| NCAAF | 2021/10/02 16:00 | Keystone Giants v Anna Maria Amcats | L | 35-55 |
| NCAAF | 2021/09/25 22:00 | Hobart Statesmen v Keystone Giants | L | 58-14 |
| NCAAF | 2021/09/18 17:00 | Keystone Giants v William Paterson Pioneers | L | 14-42 |
| NCAAF | 2021/11/13 17:00 | Kings Monarchs v Wilkes Colonels | L | 34-7 |
| NCAAF | 2021/11/06 17:00 | Wilkes Colonels v Delaware Valley Aggies | L | 0-30 |
| NCAAF | 2021/10/30 17:00 | Lycoming Warriors v Wilkes Colonels | L | 30-27 |
| NCAAF | 2021/10/23 17:00 | Wilkes Colonels v Lebanon Valley Flying Dutchmen | W | 30-20 |
| NCAAF | 2021/10/16 17:00 | Widener Pride v Wilkes Colonels | L | 30-13 |
| NCAAF | 2021/10/09 16:00 | Albright Lions v Wilkes Colonels | W | 28-31 |
| NCAAF | 2021/10/02 16:00 | Wilkes Colonels v Stevenson Mustangs | W | 21-14 |
| NCAAF | 2021/09/25 17:00 | Wilkes Colonels v Alvernia Golden Wolves | W | 23-0 |