Stadium: Mount Union Stadium Round: 1
| NCAAF | 2021/12/11 17:00 | North Central Illinois v Mount Union | L | 26-13 |
| NCAAF | 2021/12/04 17:00 | Mount Union v Muhlenberg Mules | W | 35-29 |
| NCAAF | 2021/11/27 17:00 | Mount Union v Johns Hopkins Blue Jays | W | 45-35 |
| NCAAF | 2021/11/20 17:00 | Mount Union v Washington And Lee Generals | W | 52-0 |
| NCAAF | 2021/11/13 18:30 | Marietta Pioneers v Mount Union | W | 7-37 |
| NCAAF | 2021/11/06 17:30 | Mount Union v Muskingum Muskies | W | 73-7 |
| NCAAF | 2021/10/30 18:00 | Mount Union v Ohio Northern Polar Bears | W | 42-35 |
| NCAAF | 2021/10/23 17:30 | Heidelberg Student Princes v Mount Union | W | 14-49 |
| NCAAF | 2021/11/13 18:30 | Defiance Yellow Jackets v Bluffton Beavers | L | 12-30 |
| NCAAF | 2021/11/06 17:30 | Anderson Ravens v Defiance Yellow Jackets | L | 42-14 |
| NCAAF | 2021/10/30 17:30 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 7-13 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | L | 51-0 |
| NCAAF | 2021/10/09 17:30 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 |
| NCAAF | 2021/10/02 17:30 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 14-63 |
| NCAAF | 2021/09/25 16:00 | Defiance Yellow Jackets v Alfred State Pioneers | L | 28-35 |