Stadium: Deeds Field at Piper Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Denison Big Red v Ohio Wesleyan Battling Bishops | L | 25-35 |
| NCAAF | 2021/11/06 17:00 | Hiram Terriers v Denison Big Red | W | 6-59 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | L | 27-10 |
| NCAAF | 2021/10/23 19:00 | Denison Big Red v Wooster Scots | W | 52-28 |
| NCAAF | 2021/10/16 17:00 | Kenyon Lords v Denison Big Red | W | 7-45 |
| NCAAF | 2021/10/02 19:00 | Denison Big Red v Wabash Little Giants | L | 38-39 |
| NCAAF | 2021/09/25 23:00 | Denison Big Red v Wittenberg Tigers | W | 21-16 |
| NCAAF | 2021/09/18 17:00 | Oberlin Yeomen v Denison Big Red | W | 12-59 |
| NCAAF | 2021/11/13 18:30 | Capital Crusaders v Muskingum Muskies | L | 27-46 |
| NCAAF | 2021/11/06 19:00 | Wilmington Quakers v Capital Crusaders | L | 24-21 |
| NCAAF | 2021/10/30 17:30 | Capital Crusaders v Otterbein Cardinals | L | 33-38 |
| NCAAF | 2021/10/23 17:30 | Ohio Northern Polar Bears v Capital Crusaders | W | 28-35 |
| NCAAF | 2021/10/16 17:30 | Mount Union v Capital Crusaders | L | 63-0 |
| NCAAF | 2021/10/09 17:30 | Capital Crusaders v John Carroll Blue Streaks | L | 7-38 |
| NCAAF | 2021/10/02 17:30 | Baldwin Wallace Yellow Jackets v Capital Crusaders | L | 51-0 |
| NCAAF | 2021/09/25 17:30 | Capital Crusaders v Marietta Pioneers | L | 7-37 |