Stadium: Crusader Stadium Round: 1
| NCAAF | 2021/12/18 00:00 | North Central Illinois v Mary Hardin Baylor | W | 24-57 |
| NCAAF | 2021/12/18 00:00 | Mary Hardin Baylor v North Central Illinois | W | 57-24 |
| NCAAF | 2021/12/11 20:30 | Mary Hardin Baylor v UW-Whitewater | W | 24-7 |
| NCAAF | 2021/12/04 18:00 | Linfield Wildcats v Mary Hardin Baylor | W | 24-49 |
| NCAAF | 2021/11/27 18:00 | Mary Hardin Baylor v Birmingham Southern Panthers | W | 42-7 |
| NCAAF | 2021/11/20 18:00 | Mary Hardin Baylor v Trinity Tigers | W | 13-3 |
| NCAAF | 2021/11/13 19:00 | Mcmurry Warhawks v Mary Hardin Baylor | W | 3-77 |
| NCAAF | 2021/11/06 18:00 | Mary Hardin Baylor v Howard Payne Yellow Jackets | W | 59-14 |
| NCAAF | 2021/12/04 17:00 | Mount Union v Muhlenberg Mules | L | 35-29 |
| NCAAF | 2021/11/27 17:00 | Delaware Valley Aggies v Muhlenberg Mules | W | 0-14 |
| NCAAF | 2021/11/20 17:00 | Muhlenberg Mules v Framingham State Rams | W | 45-0 |
| NCAAF | 2021/11/13 17:00 | Muhlenberg Mules v Moravian Greyhounds | W | 55-0 |
| NCAAF | 2021/11/06 17:00 | Susquehanna Crusaders v Muhlenberg Mules | W | 27-52 |
| NCAAF | 2021/10/30 17:00 | Franklin And Marshall Diplomats v Muhlenberg Mules | W | 10-27 |
| NCAAF | 2021/10/23 16:00 | Muhlenberg Mules v Juniata Eagles | W | 56-16 |
| NCAAF | 2021/10/15 23:00 | Muhlenberg Mules v Johns Hopkins Blue Jays | W | 21-6 |