Stadium: Alumni Stadium Round: 1
| NCAAF | 2021/09/04 23:00 | Centre Colonels v Hanover | L | 56-34 |
| NCAAF | 2019/09/07 17:30 | Hanover v Centre Colonels | L | 31-45 |
| NCAAF | 2018/09/01 23:00 | Centre Colonels v Hanover | L | 28-18 |
| NCAAF | 2021/11/13 18:30 | Hanover v Franklin College Grizzlies | L | 16-27 |
| NCAAF | 2021/11/06 17:30 | Mount St. Joseph Lions v Hanover | L | 23-6 |
| NCAAF | 2021/10/30 17:30 | Hanover v Manchester Spartans | W | 33-0 |
| NCAAF | 2021/10/23 17:30 | Bluffton Beavers v Hanover | W | 10-41 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | W | 51-0 |
| NCAAF | 2021/10/09 18:00 | Rose Hulman Engineers v Hanover | L | 31-21 |
| NCAAF | 2021/10/02 17:30 | Hanover v Anderson Ravens | W | 49-0 |
| NCAAF | 2021/09/18 17:00 | Albion Britons v Hanover | L | 24-14 |
| NCAAF | 2021/11/13 19:00 | Berry Vikings v Centre Colonels | W | 27-49 |
| NCAAF | 2021/11/06 18:30 | Sewanee Tigers v Centre Colonels | W | 20-30 |
| NCAAF | 2021/10/30 17:00 | Centre Colonels v Rhodes Lynx | W | 49-6 |
| NCAAF | 2021/10/23 17:00 | Millsaps Majors v Centre Colonels | W | 34-66 |
| NCAAF | 2021/10/16 17:00 | Centre Colonels v Birmingham Southern Panthers | L | 21-28 |
| NCAAF | 2021/10/09 18:30 | Trinity Tigers v Centre Colonels | L | 27-7 |
| NCAAF | 2021/10/02 17:00 | Centre Colonels v Hendrix Warriors | W | 42-21 |
| NCAAF | 2021/09/25 23:00 | Centre Colonels v Trine Thunder | W | 14-7 |