Stadium: Growney Stadium Round: 1
| NCAAF | 2021/09/04 22:00 | Buffalo State Bengals v St John Fisher Cardinals | W | 14-21 |
| NCAAF | 2019/09/07 16:00 | Buffalo State Bengals v St John Fisher Cardinals | W | 6-23 |
| NCAAF | 2018/11/10 18:00 | St John Fisher Cardinals v Buffalo State Bengals | W | 31-28 |
| NCAAF | 2021/11/13 18:00 | Utica Pioneers v St John Fisher Cardinals | L | 35-14 |
| NCAAF | 2021/11/06 17:00 | St John Fisher Cardinals v Cortland Red Dragons | L | 3-55 |
| NCAAF | 2021/10/30 18:30 | Hartwick Hawks v St John Fisher Cardinals | W | 7-28 |
| NCAAF | 2021/10/16 17:00 | St John Fisher Cardinals v Alfred Saxons | L | 35-38 |
| NCAAF | 2021/10/09 17:00 | Morrisville State Mustangs v St John Fisher Cardinals | W | 23-28 |
| NCAAF | 2021/10/02 22:00 | St John Fisher Cardinals v Brockport Golden Eagles | L | 7-34 |
| NCAAF | 2021/09/25 16:00 | Rpi Engineers v St John Fisher Cardinals | L | 41-7 |
| NCAAF | 2021/09/18 18:00 | St John Fisher Cardinals v Hobart Statesmen | L | 21-42 |
| NCAAF | 2021/11/13 17:00 | Buffalo State Bengals v St Lawrence Saints | L | 6-41 |
| NCAAF | 2021/11/06 17:00 | Hobart Statesmen v Buffalo State Bengals | L | 45-21 |
| NCAAF | 2021/10/30 16:00 | Buffalo State Bengals v Brockport Golden Eagles | L | 16-41 |
| NCAAF | 2021/10/23 18:00 | Ithaca Bombers v Buffalo State Bengals | L | 51-7 |
| NCAAF | 2021/10/16 20:00 | Buffalo State Bengals v Rochester Yellowjackets | L | 7-14 |
| NCAAF | 2021/10/09 16:00 | Rpi Engineers v Buffalo State Bengals | L | 24-16 |
| NCAAF | 2021/10/02 16:00 | Buffalo State Bengals v Union Dutchmen | L | 17-30 |
| NCAAF | 2021/09/25 18:00 | Morrisville State Mustangs v Buffalo State Bengals | L | 41-10 |