Stadium: Selby Stadium Round: 1
| NCAAF | 2021/09/04 16:00 | Otterbein Cardinals v Ohio Wesleyan Battling Bishops | W | 28-32 |
| NCAAF | 2019/09/07 18:00 | Ohio Wesleyan Battling Bishops v Otterbein Cardinals | W | 22-10 |
| NCAAF | 2018/09/01 17:30 | Otterbein Cardinals v Ohio Wesleyan Battling Bishops | L | 10-7 |
| NCAAF | 2021/11/13 18:00 | Denison Big Red v Ohio Wesleyan Battling Bishops | W | 25-35 |
| NCAAF | 2021/11/06 17:00 | Ohio Wesleyan Battling Bishops v Kenyon Lords | W | 52-17 |
| NCAAF | 2021/10/23 17:00 | Ohio Wesleyan Battling Bishops v Wabash Little Giants | W | 35-28 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | L | 24-7 |
| NCAAF | 2021/10/09 17:00 | Ohio Wesleyan Battling Bishops v Hiram Terriers | W | 34-17 |
| NCAAF | 2021/10/02 18:00 | Ohio Wesleyan Battling Bishops v Wittenberg Tigers | L | 23-24 |
| NCAAF | 2021/09/25 18:00 | Allegheny Gators v Ohio Wesleyan Battling Bishops | W | 19-28 |
| NCAAF | 2021/09/18 17:00 | Ohio Wesleyan Battling Bishops v Wooster Scots | W | 31-7 |
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | L | 33-37 |
| NCAAF | 2021/11/06 17:30 | Marietta Pioneers v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/10/30 17:30 | Capital Crusaders v Otterbein Cardinals | W | 33-38 |
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | L | 14-31 |
| NCAAF | 2021/10/16 23:00 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-19 |
| NCAAF | 2021/10/02 17:30 | Mount Union v Otterbein Cardinals | L | 55-0 |
| NCAAF | 2021/09/25 17:30 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/09/18 18:00 | Otterbein Cardinals v John Carroll Blue Streaks | L | 17-41 |