Stadium: Jack Britt Memorial Stadium Round: 1
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2019/09/21 20:00 | Hillsdale Chargers v Lake Erie | L | 34-14 |
| NCAAF | 2018/09/22 20:00 | Hillsdale Chargers v Lake Erie | L | 41-7 |
| NCAAF | 2021/11/13 18:00 | Lake Erie v Walsh U. Cavaliers | L | 7-24 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | W | 38-28 |
| NCAAF | 2021/10/23 17:00 | Ashland Eagles v Lake Erie | L | 42-41 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |
| NCAAF | 2021/09/25 22:00 | Lake Erie v Southwest Baptist University Bearcats | L | 20-28 |
| NCAAF | 2021/11/13 18:00 | Hillsdale Chargers v Ohio Dominican Panthers | W | 21-17 |
| NCAAF | 2021/11/06 17:00 | Hillsdale Chargers v Kentucky Wesleyan | W | 31-12 |
| NCAAF | 2021/10/30 17:00 | Ashland Eagles v Hillsdale Chargers | L | 28-17 |
| NCAAF | 2021/10/23 16:00 | Findlay Oilers v Hillsdale Chargers | W | 29-34 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | L | 14-33 |
| NCAAF | 2021/10/09 18:00 | Hillsdale Chargers v Walsh U. Cavaliers | W | 20-3 |
| NCAAF | 2021/10/02 20:00 | Tiffin Dragons v Hillsdale Chargers | W | 21-24 |
| NCAAF | 2021/09/25 20:00 | Hillsdale Chargers v Missouri S&t Miners | W | 38-31 |