Stadium: Kimbrough Memorial Stadium Round: 1
| NCAAF | 2021/11/13 17:00 | West Texas AM Buffaloes v Bethel Threshers | W | 52-9 |
| NCAAF | 2021/11/06 23:00 | West Texas AM Buffaloes v Midwestern State University Mustangs | W | 15-12 |
| NCAAF | 2021/10/31 00:00 | Texas AM Kingsville Javelinas v West Texas AM Buffaloes | W | 23-35 |
| NCAAF | 2021/10/23 23:00 | West Texas AM Buffaloes v Texas A&M-Commerce | L | 3-15 |
| NCAAF | 2021/10/17 00:00 | Eastern New Mexico University Greyhounds v West Texas AM Buffaloes | W | 24-44 |
| NCAAF | 2021/10/10 00:00 | West Texas AM Buffaloes v Angelo State Univeristy Rams | W | 31-15 |
| NCAAF | 2021/10/02 20:05 | Western Oregon v West Texas AM Buffaloes | L | 41-38 |
| NCAAF | 2021/09/26 00:00 | West Texas AM Buffaloes v Colorado School of Mines | L | 13-21 |
| NCAAF | 2021/11/20 20:00 | Western State Colorado Mountaineers v Nebraska Kearney | L | 24-31 |
| NCAAF | 2021/11/13 20:00 | Western State Colorado Mountaineers v Colorado State Pueblo Thunderwolves | W | 14-7 |
| NCAAF | 2021/11/06 19:00 | Western State Colorado Mountaineers v Lincoln Oaklanders | W | 72-6 |
| NCAAF | 2021/10/30 19:00 | Western State Colorado Mountaineers v Colorado Mesa University Mavericks | W | 23-9 |
| NCAAF | 2021/10/23 18:00 | South Dakota Mines Hardrockers v Western State Colorado Mountaineers | W | 21-42 |
| NCAAF | 2021/10/16 19:00 | Western State Colorado Mountaineers v Black Hills State | W | 44-28 |
| NCAAF | 2021/10/09 19:00 | Western State Colorado Mountaineers v N. Mexico H. Cowboys | W | 45-38 |
| NCAAF | 2021/10/02 18:00 | Colorado School of Mines v Western State Colorado Mountaineers | L | 20-14 |