Stadium: Memorial Stadium Round: 1
| NCAAF | 2021/11/13 19:00 | Midwestern State University Mustangs v Texas-Permian Basin Falcons | W | 36-30 |
| NCAAF | 2021/11/06 23:00 | West Texas AM Buffaloes v Midwestern State University Mustangs | L | 15-12 |
| NCAAF | 2021/10/31 00:00 | Midwestern State University Mustangs v Western New Mexico Mustangs | W | 52-10 |
| NCAAF | 2021/10/23 23:00 | Tarleton State v Midwestern State University Mustangs | L | 17-14 |
| NCAAF | 2021/10/10 00:00 | Midwestern State University Mustangs v Texas AM Kingsville Javelinas | W | 30-13 |
| NCAAF | 2021/10/03 01:00 | Central Washington v Midwestern State University Mustangs | L | 30-20 |
| NCAAF | 2021/09/26 00:00 | Midwestern State University Mustangs v Eastern New Mexico University Greyhounds | W | 31-24 |
| NCAAF | 2021/09/18 23:00 | Angelo State Univeristy Rams v Midwestern State University Mustangs | W | 17-35 |
| NCAAF | 2021/11/13 20:00 | Western State Colorado Mountaineers v Colorado State Pueblo Thunderwolves | L | 14-7 |
| NCAAF | 2021/11/06 20:00 | Colorado State Pueblo Thunderwolves v Colorado School of Mines | L | 12-28 |
| NCAAF | 2021/10/30 18:00 | Fort Lewis Skyhawks v Colorado State Pueblo Thunderwolves | W | 0-73 |
| NCAAF | 2021/10/23 20:00 | Colorado State Pueblo Thunderwolves v Adams State Grizzlies | W | 35-28 |
| NCAAF | 2021/10/16 19:00 | N. Mexico H. Cowboys v Colorado State Pueblo Thunderwolves | L | 28-21 |
| NCAAF | 2021/10/09 19:00 | Chadron State Eagles v Colorado State Pueblo Thunderwolves | W | 17-42 |
| NCAAF | 2021/10/02 20:00 | Colorado State Pueblo Thunderwolves v Colorado Mesa University Mavericks | W | 19-13 |
| NCAAF | 2021/09/25 22:00 | South Dakota Mines Hardrockers v Colorado State Pueblo Thunderwolves | W | 7-49 |