Stadium: Jamieson Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Maryville Scots v Greensboro Pride | L | 49-14 |
| NCAAF | 2021/11/06 16:00 | Greensboro Pride v Methodist Monarchs | L | 14-40 |
| NCAAF | 2021/10/30 17:00 | Lagrange Panthers v Greensboro Pride | L | 29-14 |
| NCAAF | 2021/10/23 16:00 | Greensboro Pride v Huntingdon Hawks | L | 3-42 |
| NCAAF | 2021/10/16 17:00 | Southern Virginia Knights v Greensboro Pride | L | 31-14 |
| NCAAF | 2021/10/09 16:00 | Nc Wesleyan Battling Bishops v Greensboro Pride | L | 21-0 |
| NCAAF | 2021/10/02 20:00 | Greensboro Pride v Brevard Tornados | L | 7-27 |
| NCAAF | 2021/09/25 16:00 | Greensboro Pride v Gallaudet Bison | L | 42-49 |
| NCAAF | 2021/11/13 19:00 | Bridgewater Eagles v Guilford Quakers | L | 43-0 |
| NCAAF | 2021/11/06 17:00 | Guilford Quakers v Emory And Henry Wasps | L | 13-66 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | L | 57-35 |
| NCAAF | 2021/10/16 17:00 | Guilford Quakers v Randolph Macon Yellow Jackets | L | 0-58 |
| NCAAF | 2021/10/09 16:00 | Guilford Quakers v Shenandoah Hornets | L | 25-52 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | L | 27-28 |
| NCAAF | 2021/09/18 17:00 | Washington And Lee Generals v Guilford Quakers | L | 52-0 |
| NCAAF | 2021/09/04 23:00 | Guilford Quakers v Greensboro Pride | W | 21-7 |