Stadium: Frank M. Lindsay Field Round: 1
| NCAAF | 2021/11/13 19:00 | Millikin Big Blue v Wheaton Thunder | L | 7-49 |
| NCAAF | 2021/11/06 18:00 | North Park Vikings v Millikin Big Blue | W | 0-21 |
| NCAAF | 2021/10/30 23:00 | Millikin Big Blue v North Central Illinois | L | 27-54 |
| NCAAF | 2021/10/23 23:00 | Millikin Big Blue v Washington Bears | L | 13-55 |
| NCAAF | 2021/10/16 18:00 | Illinois Wesleyan Titans v Millikin Big Blue | L | 14-0 |
| NCAAF | 2021/10/09 18:00 | Elmhurst Bluejays v Millikin Big Blue | L | 28-7 |
| NCAAF | 2021/10/02 18:00 | Millikin Big Blue v Carthage Red Men | L | 42-63 |
| NCAAF | 2021/09/25 23:00 | Millikin Big Blue v Carroll Pioneers | W | 32-25 |
| NCAAF | 2021/11/20 18:00 | UW-Whitewater v Greenville Panthers | L | 69-7 |
| NCAAF | 2021/11/13 18:00 | Greenville Panthers v Minnesota Morris Cougars | W | 47-21 |
| NCAAF | 2021/11/06 17:00 | Finlandia Lions v Greenville Panthers | W | 2-28 |
| NCAAF | 2021/10/30 18:00 | Greenville Panthers v Crown Storm | W | 55-30 |
| NCAAF | 2021/10/16 18:00 | Westminster Blue Jays v Greenville Panthers | W | 14-42 |
| NCAAF | 2021/10/09 17:00 | Greenville Panthers v Northwestern Eagles | W | 35-23 |
| NCAAF | 2021/10/02 17:00 | Martin Luther Knights v Greenville Panthers | W | 14-21 |
| NCAAF | 2021/09/25 18:00 | Trinity I. Trojans v Greenville Panthers | L | 26-21 |