Stadium: Charles A. Gaetano Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Utica Pioneers v St John Fisher Cardinals | W | 35-14 |
| NCAAF | 2021/11/06 17:00 | Alfred Saxons v Utica Pioneers | L | 24-17 |
| NCAAF | 2021/10/30 16:00 | Utica Pioneers v Morrisville State Mustangs | W | 20-3 |
| NCAAF | 2021/10/23 17:00 | Cortland Red Dragons v Utica Pioneers | L | 45-0 |
| NCAAF | 2021/10/16 22:00 | Brockport Golden Eagles v Utica Pioneers | L | 26-14 |
| NCAAF | 2021/10/02 18:30 | Hartwick Hawks v Utica Pioneers | W | 10-16 |
| NCAAF | 2021/09/25 17:00 | Utica Pioneers v Union Dutchmen | L | 9-30 |
| NCAAF | 2021/09/18 22:00 | Utica Pioneers v Western New England Golden Bears | W | 37-28 |
| NCAAF | 2021/11/13 17:00 | Rochester Yellowjackets v Hobart Statesmen | L | 0-31 |
| NCAAF | 2021/11/06 17:00 | Hartwick Hawks v Rochester Yellowjackets | W | 28-42 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | L | 34-10 |
| NCAAF | 2021/10/23 16:00 | Rochester Yellowjackets v Union Dutchmen | L | 9-35 |
| NCAAF | 2021/10/16 20:00 | Buffalo State Bengals v Rochester Yellowjackets | W | 7-14 |
| NCAAF | 2021/10/09 16:00 | Rochester Yellowjackets v Ithaca Bombers | L | 14-37 |
| NCAAF | 2021/10/02 16:00 | Rpi Engineers v Rochester Yellowjackets | L | 38-22 |
| NCAAF | 2021/09/18 16:00 | Brockport Golden Eagles v Rochester Yellowjackets | L | 16-7 |