Stadium: Bud and Jackie Sellick Bowl Round: 1
Home Manager: Mike Uremovich Away Manager:
| NCAAF | 2021/11/20 17:00 | Butler v Marist | W | 28-21 |
| NCAAF | 2021/11/13 17:00 | Valparaiso v Butler | L | 47-3 |
| NCAAF | 2021/10/30 17:00 | Butler v Dayton | L | 31-38 |
| NCAAF | 2021/10/23 17:00 | Davidson Wildcats v Butler | L | 49-35 |
| NCAAF | 2021/10/16 19:00 | Butler v Morehead State | L | 8-31 |
| NCAAF | 2021/10/09 16:00 | San Diego v Butler | L | 52-21 |
| NCAAF | 2021/10/02 16:00 | Drake Bulldogs v Butler | L | 6-3 |
| NCAAF | 2021/09/25 17:00 | Butler v St. Thomas (MN) | L | 0-36 |