Stadium: A.W. Mumford Stadium Round: 1
Home Manager: Eric Dooley Away Manager:
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | W | 35-38 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | L | 48-21 |
| NCAAF | 2021/10/16 19:00 | Southern v Arkansas Pine Bluff | W | 34-7 |
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | L | 31-35 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | W | 38-25 |
| NCAAF | 2022/08/27 20:00 | Florida Memorial University Lions v Edward Waters Tigers | W | 39-34 |