Stadium: Bowman Gray Stadium Round: 1
| NCAAF | 2021/11/06 18:00 | Fayetteville State Broncos v Winston-Salem State | L | 10-3 |
| NCAAF | 2021/10/30 17:00 | Shaw Bears v Winston-Salem State | L | 38-14 |
| NCAAF | 2021/10/23 17:00 | Winston-Salem State v Livingstone C. BB | W | 21-0 |
| NCAAF | 2021/10/16 17:30 | Winston-Salem State v St Augustines Falcons | W | 41-0 |
| NCAAF | 2021/10/09 17:00 | Johnson C Smith GB v Winston-Salem State | W | 12-26 |
| NCAAF | 2021/10/02 22:00 | Chowan Hawks v Winston-Salem State | L | 73-7 |
| NCAAF | 2021/09/25 17:30 | Winston-Salem State v Elizabeth City State Vikings | L | 14-19 |
| NCAAF | 2021/09/18 22:00 | North Carolina Central v Winston-Salem State | L | 20-13 |
| NCAAF | 2021/11/06 17:00 | Kentucky Thorobreds v Central State | L | 63-0 |
| NCAAF | 2021/10/30 17:00 | Central State v Lane College Dragons | L | 14-16 |
| NCAAF | 2021/10/23 18:00 | Edward Waters Tigers v Central State | L | 56-19 |
| NCAAF | 2021/10/16 17:00 | Central State v Tuskegee | L | 0-29 |
| NCAAF | 2021/10/09 18:00 | Fort Valley State v Central State | L | 35-14 |
| NCAAF | 2021/10/02 17:00 | Central State v Allen Yellow Jackets | L | 34-46 |
| NCAAF | 2021/09/25 23:00 | Miles Golden Bears v Central State | L | 55-4 |
| NCAAF | 2021/09/18 17:00 | Shaw Bears v Central State | L | 52-0 |