Stadium: Memorial Stadium Round: 1
| NCAAF | 2021/11/06 16:00 | Edinboro v Clarion Golden Eagles | L | 17-10 |
| NCAAF | 2021/10/30 16:00 | Clarion Golden Eagles v Mercyhurst | L | 20-38 |
| NCAAF | 2021/10/23 16:00 | Clarion Golden Eagles v Seton Hill Griffins | L | 0-49 |
| NCAAF | 2021/10/09 18:00 | Clarion Golden Eagles v Iup Crimson Hawks | L | 21-58 |
| NCAAF | 2021/10/02 22:00 | Slippery Rock v Clarion Golden Eagles | L | 75-0 |
| NCAAF | 2021/09/25 17:00 | Gannon University Golden Knights v Clarion Golden Eagles | L | 56-21 |
| NCAAF | 2021/09/18 17:00 | Clarion Golden Eagles v Shippensburg Raiders | L | 33-62 |
| NCAAF | 2021/09/11 17:00 | Clarion Golden Eagles v Millersville University of Pennsylvania Marauders | L | 10-21 |
| NCAAF | 2021/11/13 18:00 | Frostburg State v West Liberty Hilltoppers | L | 56-3 |
| NCAAF | 2021/11/06 18:00 | West Liberty Hilltoppers v West Virginia State Yellow Jackets | L | 28-33 |
| NCAAF | 2021/10/30 16:00 | West Liberty Hilltoppers v Unc Pembroke Braves | L | 17-27 |
| NCAAF | 2021/10/23 17:00 | Wheeling v West Liberty Hilltoppers | L | 26-20 |
| NCAAF | 2021/10/16 17:00 | West Liberty Hilltoppers v Fairmont State | W | 52-31 |
| NCAAF | 2021/10/09 17:00 | Concord University Mountain Lions v West Liberty Hilltoppers | L | 20-16 |
| NCAAF | 2021/10/02 17:00 | West Liberty Hilltoppers v Glenville State Pioneers | W | 20-19 |
| NCAAF | 2021/09/25 17:00 | W. Virginia Bobcats v West Liberty Hilltoppers | W | 0-31 |