Stadium: Carnie Smith Stadium Round: 1
| NCAAF | 2021/09/03 00:00 | Central Missouri Mules v Pittsburgh State Gorillas | W | 16-35 |
| NCAAF | 2019/10/26 18:00 | Central Missouri Mules v Pittsburgh State Gorillas | L | 36-28 |
| NCAAF | 2018/10/20 19:05 | Pittsburgh State Gorillas v Central Missouri Mules | W | 48-28 |
| NCAAF | 2021/11/13 19:00 | Fort Hays State University Tigers v Pittsburgh State Gorillas | W | 24-34 |
| NCAAF | 2021/11/06 18:00 | Pittsburgh State Gorillas v Washburn Ichabods Football | L | 26-28 |
| NCAAF | 2021/10/30 18:00 | Pittsburgh State Gorillas v Central Oklahoma | W | 26-20 |
| NCAAF | 2021/10/23 21:00 | Missouri Western Griffons v Pittsburgh State Gorillas | W | 14-34 |
| NCAAF | 2021/10/16 18:00 | Pittsburgh State Gorillas v Blue Tigers | W | 59-7 |
| NCAAF | 2021/10/09 18:30 | NW Missouri State v Pittsburgh State Gorillas | L | 20-19 |
| NCAAF | 2021/10/02 19:00 | Missouri Southern Lions v Pittsburgh State Gorillas | W | 16-20 |
| NCAAF | 2021/09/26 00:00 | Pittsburgh State Gorillas v Emporia State | W | 30-28 |
| NCAAF | 2021/11/13 19:00 | Central Missouri Mules v Central Oklahoma | W | 30-29 |
| NCAAF | 2021/11/06 18:00 | Missouri Western Griffons v Central Missouri Mules | L | 59-28 |
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | W | 35-77 |
| NCAAF | 2021/10/23 18:30 | Central Missouri Mules v Fort Hays State University Tigers | L | 17-21 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | L | 30-28 |
| NCAAF | 2021/10/09 18:00 | Central Missouri Mules v Emporia State | W | 45-38 |
| NCAAF | 2021/10/02 19:00 | Northeastern State Riverhawks v Central Missouri Mules | W | 10-41 |
| NCAAF | 2021/09/25 18:00 | Central Missouri Mules v Nebraska Kearney | L | 28-31 |