Stadium: McConnell Family Stadium Round: 1
| NCAAF | 2021/11/13 18:05 | East Stroudsburg Warriors v Gannon University Golden Knights | W | 10-13 |
| NCAAF | 2021/11/06 16:00 | Mercyhurst v Gannon University Golden Knights | L | 24-13 |
| NCAAF | 2021/10/30 16:00 | Gannon University Golden Knights v Slippery Rock | L | 21-63 |
| NCAAF | 2021/10/23 16:00 | Gannon University Golden Knights v Edinboro | W | 21-18 |
| NCAAF | 2021/10/16 20:00 | Seton Hill Griffins v Gannon University Golden Knights | W | 10-14 |
| NCAAF | 2021/10/09 16:00 | Gannon University Golden Knights v California Vulcans | L | 17-38 |
| NCAAF | 2021/10/02 18:00 | Iup Crimson Hawks v Gannon University Golden Knights | L | 28-23 |
| NCAAF | 2021/09/25 17:00 | Gannon University Golden Knights v Clarion Golden Eagles | W | 56-21 |
| NCAAF | 2021/11/13 17:00 | West Virginia State Yellow Jackets v University of Charleston Golden Eagles | W | 13-38 |
| NCAAF | 2021/11/06 16:00 | University of Charleston Golden Eagles v Wheeling | W | 38-20 |
| NCAAF | 2021/10/28 23:00 | University of Charleston Golden Eagles v W. Virginia Bobcats | W | 45-6 |
| NCAAF | 2021/10/23 18:00 | Unc Pembroke Braves v University of Charleston Golden Eagles | L | 21-14 |
| NCAAF | 2021/10/16 16:00 | University of Charleston Golden Eagles v Concord University Mountain Lions | W | 48-3 |
| NCAAF | 2021/10/09 17:00 | Glenville State Pioneers v University of Charleston Golden Eagles | W | 9-20 |
| NCAAF | 2021/10/02 16:00 | University of Charleston Golden Eagles v Notre Dame Falcons | W | 38-28 |
| NCAAF | 2021/09/25 17:00 | Alderson Broaddus Battlers v University of Charleston Golden Eagles | W | 7-69 |