Stadium: Frost-Kalnow Stadium Round: 1
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | W | 34-21 |
| NCAAF | 2019/09/28 20:00 | Tiffin Dragons v Ohio Dominican Panthers | W | 41-31 |
| NCAAF | 2018/10/20 20:00 | Tiffin Dragons v Ohio Dominican Panthers | W | 24-23 |
| NCAAF | 2022/09/03 18:00 | Walsh U. Cavaliers v Tiffin Dragons | W | 0-42 |
| NCAAF | 2021/11/13 17:00 | Findlay Oilers v Tiffin Dragons | L | 26-21 |
| NCAAF | 2021/11/06 16:00 | Walsh U. Cavaliers v Tiffin Dragons | W | 16-56 |
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | W | 34-21 |
| NCAAF | 2021/10/23 16:00 | Kentucky Wesleyan v Tiffin Dragons | W | 28-34 |
| NCAAF | 2021/10/16 17:00 | Tiffin Dragons v Ashland Eagles | W | 27-21 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | W | 17-35 |
| NCAAF | 2021/10/02 20:00 | Tiffin Dragons v Hillsdale Chargers | L | 21-24 |
| NCAAF | 2022/09/03 16:00 | Ohio Dominican Panthers v Findlay Oilers | W | 28-14 |
| NCAAF | 2021/11/13 18:00 | Hillsdale Chargers v Ohio Dominican Panthers | L | 21-17 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | W | 31-0 |
| NCAAF | 2021/10/30 20:00 | Tiffin Dragons v Ohio Dominican Panthers | L | 34-21 |
| NCAAF | 2021/10/23 16:00 | Ohio Dominican Panthers v Walsh U. Cavaliers | W | 56-17 |
| NCAAF | 2021/10/16 16:00 | Ohio Dominican Panthers v Findlay Oilers | L | 14-21 |
| NCAAF | 2021/10/09 23:00 | Ashland Eagles v Ohio Dominican Panthers | W | 24-34 |
| NCAAF | 2021/10/02 17:00 | Kentucky Wesleyan v Ohio Dominican Panthers | W | 30-32 |