Stadium: Milam Stadium Round: 1
| NCAAF | 2021/09/11 23:00 | Southern Arkansas Muleriders v Southwestern Oklahoma State Bulldogs | L | 42-27 |
| NCAAF | 2019/10/05 19:00 | Southern Arkansas Muleriders v Southwestern Oklahoma State Bulldogs | L | 42-20 |
| NCAAF | 2018/09/15 23:00 | Southwestern Oklahoma State Bulldogs v Southern Arkansas Muleriders | L | 12-36 |
| NCAAF | 2022/09/02 00:00 | Henderson State Reddies v Southwestern Oklahoma State Bulldogs | L | 30-13 |
| NCAAF | 2021/11/13 21:00 | Northwestern Oklahoma State Rangers v Southwestern Oklahoma State Bulldogs | L | 31-28 |
| NCAAF | 2021/11/06 19:00 | Southwestern Oklahoma State Bulldogs v Harding Bisons | L | 7-55 |
| NCAAF | 2021/10/30 22:30 | Southwestern Oklahoma State Bulldogs v Arkansas Tech Wonder Boys | L | 14-15 |
| NCAAF | 2021/10/23 19:00 | Southwestern Oklahoma State Bulldogs v East Central Tigers | L | 34-44 |
| NCAAF | 2021/10/14 23:00 | Southern Nazarene v Southwestern Oklahoma State Bulldogs | L | 30-22 |
| NCAAF | 2021/10/09 19:00 | Southwestern Oklahoma State Bulldogs v Ouachita Baptist Tigers | L | 10-30 |
| NCAAF | 2021/10/02 19:00 | Arkansas Monticello Boll Weevils v Southwestern Oklahoma State Bulldogs | L | 18-16 |
| NCAAF | 2022/09/01 23:00 | Southern Arkansas Muleriders v Northwestern Oklahoma State Rangers | W | 62-31 |
| NCAAF | 2021/11/13 20:00 | Southern Arkansas Muleriders v Arkansas Monticello Boll Weevils | L | 37-73 |
| NCAAF | 2021/11/06 18:00 | Southern Nazarene v Southern Arkansas Muleriders | W | 10-31 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2021/10/09 19:30 | Southern Arkansas Muleriders v Southeastern Oklahoma State Savage Storm | L | 24-38 |
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | L | 38-17 |