Stadium: Steele Stadium Round: 1
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | L | 38-28 |
| NCAAF | 2019/09/28 18:00 | Lake Erie v Kentucky Wesleyan | L | 49-42 |
| NCAAF | 2018/10/20 18:00 | Kentucky Wesleyan v Lake Erie | W | 46-6 |
| NCAAF | 2022/09/03 17:00 | Northwood Timberwolves v Kentucky Wesleyan | L | 55-13 |
| NCAAF | 2021/11/13 18:00 | Kentucky Wesleyan v Ashland Eagles | L | 0-17 |
| NCAAF | 2021/11/06 17:00 | Hillsdale Chargers v Kentucky Wesleyan | L | 31-12 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | L | 38-28 |
| NCAAF | 2021/10/23 16:00 | Kentucky Wesleyan v Tiffin Dragons | L | 28-34 |
| NCAAF | 2021/10/16 17:00 | Walsh U. Cavaliers v Kentucky Wesleyan | W | 13-23 |
| NCAAF | 2021/10/09 17:00 | Findlay Oilers v Kentucky Wesleyan | L | 31-19 |
| NCAAF | 2021/10/02 17:00 | Kentucky Wesleyan v Ohio Dominican Panthers | L | 30-32 |
| NCAAF | 2022/09/03 19:00 | Lake Erie v Hillsdale Chargers | L | 31-35 |
| NCAAF | 2021/11/13 18:00 | Lake Erie v Walsh U. Cavaliers | L | 7-24 |
| NCAAF | 2021/11/06 16:00 | Ohio Dominican Panthers v Lake Erie | L | 31-0 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | W | 38-28 |
| NCAAF | 2021/10/23 17:00 | Ashland Eagles v Lake Erie | L | 42-41 |
| NCAAF | 2021/10/16 17:00 | Hillsdale Chargers v Lake Erie | W | 14-33 |
| NCAAF | 2021/10/09 19:00 | Lake Erie v Tiffin Dragons | L | 17-35 |
| NCAAF | 2021/10/02 19:00 | Lake Erie v Findlay Oilers | L | 10-37 |