Stadium: Macalester Stadium Round: 1
| NCAAF | 2022/09/03 23:00 | Minnesota Morris Cougars v Macalester Scots | W | 24-45 |
| NCAAF | 2021/11/06 18:00 | St Scholastica Saints v Macalester Scots | W | 14-28 |
| NCAAF | 2021/10/31 00:00 | Macalester Scots v Hamline Pipers | W | 23-13 |
| NCAAF | 2021/10/23 18:00 | Bethel Royals v Macalester Scots | L | 63-10 |
| NCAAF | 2021/10/16 18:00 | Augsburg Auggies v Macalester Scots | L | 37-29 |
| NCAAF | 2021/10/09 18:00 | Macalester Scots v Concordia-Moorhead Cobbers | L | 27-34 |
| NCAAF | 2021/10/02 18:00 | Macalester Scots v Carleton Knights | L | 10-24 |
| NCAAF | 2021/09/25 18:00 | St Olaf Oles v Macalester Scots | L | 40-27 |
| NCAAF | 2022/09/03 18:00 | Martin Luther Knights v Concordia Wisconsin Falcons | L | 7-28 |
| NCAAF | 2021/11/13 19:00 | Martin Luther Knights v Northwestern Eagles | W | 27-21 |
| NCAAF | 2021/11/06 17:00 | Westminster Blue Jays v Martin Luther Knights | W | 14-28 |
| NCAAF | 2021/10/23 18:00 | Martin Luther Knights v Minnesota Morris Cougars | W | 39-0 |
| NCAAF | 2021/10/09 18:00 | Crown Storm v Martin Luther Knights | W | 18-35 |
| NCAAF | 2021/10/02 17:00 | Martin Luther Knights v Greenville Panthers | L | 14-21 |
| NCAAF | 2021/09/25 18:00 | Martin Luther Knights v Alma College Scots | L | 27-35 |
| NCAAF | 2021/09/18 18:00 | St Johns Johnnies v Martin Luther Knights | L | 55-7 |