Stadium: W. B. Adams Stadium Round: 1
| NCAAF | 2022/09/01 23:00 | Virginia Wise Highland Cavaliers v Ferrum Panthers | L | 41-9 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | L | 41-23 |
| NCAAF | 2021/11/06 17:00 | Washington And Lee Generals v Ferrum Panthers | L | 28-24 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | W | 57-35 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | L | 42-28 |
| NCAAF | 2021/10/16 17:00 | Ferrum Panthers v Shenandoah Hornets | W | 24-23 |
| NCAAF | 2021/10/09 18:00 | Bridgewater Eagles v Ferrum Panthers | W | 10-14 |
| NCAAF | 2021/10/02 17:00 | Ferrum Panthers v Randolph Macon Yellow Jackets | L | 21-44 |
| NCAAF | 2021/11/13 18:30 | Capital Crusaders v Muskingum Muskies | W | 27-46 |
| NCAAF | 2021/11/06 17:30 | Mount Union v Muskingum Muskies | L | 73-7 |
| NCAAF | 2021/10/30 17:30 | Muskingum Muskies v Heidelberg Student Princes | L | 14-49 |
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | W | 14-31 |
| NCAAF | 2021/10/16 20:00 | Muskingum Muskies v Baldwin Wallace Yellow Jackets | L | 10-49 |
| NCAAF | 2021/10/02 17:30 | John Carroll Blue Streaks v Muskingum Muskies | L | 29-7 |
| NCAAF | 2021/09/25 17:30 | Muskingum Muskies v Wilmington Quakers | W | 62-14 |
| NCAAF | 2021/09/18 23:00 | Marietta Pioneers v Muskingum Muskies | L | 18-0 |