Stadium: Lewis C. Everett Stadium Round: 1
| NCAAF | 2022/09/03 17:00 | Wabash Little Giants v Hampden Sydney Tigers | L | 52-48 |
| NCAAF | 2021/11/13 18:00 | Randolph Macon Yellow Jackets v Hampden Sydney Tigers | L | 37-14 |
| NCAAF | 2021/11/06 17:00 | Hampden Sydney Tigers v Bridgewater Eagles | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | The Apprentice School Builders v Hampden Sydney Tigers | W | 21-38 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | W | 42-28 |
| NCAAF | 2021/10/16 17:00 | Emory And Henry Wasps v Hampden Sydney Tigers | L | 37-13 |
| NCAAF | 2021/10/02 17:00 | Hampden Sydney Tigers v Washington And Lee Generals | L | 30-32 |
| NCAAF | 2021/09/25 17:00 | Guilford Quakers v Hampden Sydney Tigers | W | 27-28 |
| NCAAF | 2022/09/03 17:00 | Widener Pride v Rowan Profs | L | 20-42 |
| NCAAF | 2021/11/13 17:00 | Delaware Valley Aggies v Widener Pride | L | 27-0 |
| NCAAF | 2021/11/06 17:00 | Widener Pride v Lycoming Warriors | W | 17-0 |
| NCAAF | 2021/10/23 17:00 | Stevenson Mustangs v Widener Pride | L | 29-24 |
| NCAAF | 2021/10/16 17:00 | Widener Pride v Wilkes Colonels | W | 30-13 |
| NCAAF | 2021/10/09 16:00 | Alvernia Golden Wolves v Widener Pride | W | 7-37 |
| NCAAF | 2021/10/02 17:00 | Widener Pride v Fdu Florham Devils | L | 3-27 |
| NCAAF | 2021/09/25 16:00 | Albright Lions v Widener Pride | W | 7-21 |