Stadium: Dwight T. Reed Stadium Round: 1
| NCAAF | 2022/09/01 23:00 | Washburn Ichabods Football v Blue Tigers | L | 45-3 |
| NCAAF | 2021/11/13 17:00 | Blue Tigers v Missouri Western Griffons | L | 12-41 |
| NCAAF | 2021/11/06 18:00 | Emporia State v Blue Tigers | L | 56-21 |
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | L | 35-77 |
| NCAAF | 2021/10/23 19:00 | Nebraska Kearney v Blue Tigers | L | 56-0 |
| NCAAF | 2021/10/16 18:00 | Pittsburgh State Gorillas v Blue Tigers | L | 59-7 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | L | 32-52 |
| NCAAF | 2021/10/02 19:00 | Central Oklahoma v Blue Tigers | L | 69-28 |
| NCAAF | 2022/09/02 00:00 | NW Missouri State v Fort Hays State University Tigers | W | 33-19 |
| NCAAF | 2021/12/04 18:00 | Ferris State v NW Missouri State | L | 41-20 |
| NCAAF | 2021/11/27 19:00 | Harding Bisons v NW Missouri State | W | 9-28 |
| NCAAF | 2021/11/20 19:00 | NW Missouri State v Central Washington | W | 50-21 |
| NCAAF | 2021/11/13 19:30 | NW Missouri State v Emporia State | W | 35-7 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | W | 7-49 |
| NCAAF | 2021/10/30 19:00 | NW Missouri State v Nebraska Kearney | W | 66-13 |
| NCAAF | 2021/10/23 18:00 | Northeastern State Riverhawks v NW Missouri State | W | 7-59 |