Stadium: Cheek Field and Farris Stadium Round: 1
| NCAAF | 2021/09/11 17:00 | Maryville Scots v Centre Colonels | W | 21-40 |
| NCAAF | 2019/09/14 23:00 | Centre Colonels v Maryville Scots | W | 27-22 |
| NCAAF | 2018/09/08 17:00 | Maryville Scots v Centre Colonels | W | 6-40 |
| NCAAF | 2022/09/03 17:00 | Hanover v Centre Colonels | W | 29-31 |
| NCAAF | 2021/11/13 19:00 | Berry Vikings v Centre Colonels | W | 27-49 |
| NCAAF | 2021/11/06 18:30 | Sewanee Tigers v Centre Colonels | W | 20-30 |
| NCAAF | 2021/10/30 17:00 | Centre Colonels v Rhodes Lynx | W | 49-6 |
| NCAAF | 2021/10/23 17:00 | Millsaps Majors v Centre Colonels | W | 34-66 |
| NCAAF | 2021/10/16 17:00 | Centre Colonels v Birmingham Southern Panthers | L | 21-28 |
| NCAAF | 2021/10/09 18:30 | Trinity Tigers v Centre Colonels | L | 27-7 |
| NCAAF | 2021/10/02 17:00 | Centre Colonels v Hendrix Warriors | W | 42-21 |
| NCAAF | 2022/09/03 18:00 | Maryville Scots v Berry Vikings | L | 24-31 |
| NCAAF | 2021/11/13 18:00 | Maryville Scots v Greensboro Pride | W | 49-14 |
| NCAAF | 2021/11/06 18:00 | Huntingdon Hawks v Maryville Scots | L | 52-33 |
| NCAAF | 2021/10/23 18:00 | Maryville Scots v Lagrange Panthers | W | 52-16 |
| NCAAF | 2021/10/16 16:00 | Nc Wesleyan Battling Bishops v Maryville Scots | W | 26-31 |
| NCAAF | 2021/10/09 18:00 | Brevard Tornados v Maryville Scots | L | 31-0 |
| NCAAF | 2021/10/02 17:00 | Maryville Scots v Southern Virginia Knights | W | 38-17 |
| NCAAF | 2021/09/25 22:00 | Averett Cougars v Maryville Scots | L | 47-10 |