Stadium: J. Henry “Hank” Cameron Stadium Round: 1
| NCAAF | 2021/09/11 17:00 | Plymouth State Panthers v Husson Eagles | W | 7-10 |
| NCAAF | 2018/11/10 17:00 | Plymouth State Panthers v Husson Eagles | W | 10-21 |
| NCAAF | 2022/09/03 16:00 | Umass Dartmouth Corsairs v Husson Eagles | L | 35-14 |
| NCAAF | 2021/11/13 18:00 | Western New England Golden Bears v Husson Eagles | L | 35-10 |
| NCAAF | 2021/11/06 16:00 | Husson Eagles v Salve Regina Seahawks | W | 24-10 |
| NCAAF | 2021/10/30 16:00 | Nichols Bison v Husson Eagles | W | 12-14 |
| NCAAF | 2021/10/23 17:00 | University of New England Noreasters v Husson Eagles | W | 14-41 |
| NCAAF | 2021/10/16 17:00 | Husson Eagles v Endicott Gulls | L | 17-24 |
| NCAAF | 2021/10/09 17:00 | Husson Eagles v Curry Colonels | W | 21-14 |
| NCAAF | 2021/09/25 17:00 | Husson Eagles v Springfield Pride | W | 26-21 |
| NCAAF | 2022/09/03 16:00 | Plymouth State Panthers v Castleton Spartans | W | 20-7 |
| NCAAF | 2021/11/13 17:00 | Umass Dartmouth Corsairs v Plymouth State Panthers | L | 28-7 |
| NCAAF | 2021/11/06 17:00 | Plymouth State Panthers v Massachusetts Maritime Buccaneers | W | 27-7 |
| NCAAF | 2021/10/30 16:00 | Westfield State Owls v Plymouth State Panthers | W | 7-17 |
| NCAAF | 2021/10/23 17:00 | Plymouth State Panthers v Worcester State Lancers | W | 42-14 |
| NCAAF | 2021/10/16 16:00 | Plymouth State Panthers v Fitchburg State Falcons | W | 36-0 |
| NCAAF | 2021/10/09 19:00 | Western Connecticut Colonials v Plymouth State Panthers | W | 13-16 |
| NCAAF | 2021/10/02 17:00 | Plymouth State Panthers v Framingham State Rams | L | 0-33 |