Stadium: Mangelsdorf Field Round: 1
| NCAAF | 2022/09/03 17:00 | Alfred State Pioneers v Misericordia Cougars | L | 17-14 |
| NCAAF | 2021/11/06 17:00 | Lebanon Valley Flying Dutchmen v Misericordia Cougars | L | 31-17 |
| NCAAF | 2021/10/30 17:00 | Misericordia Cougars v Kings Monarchs | W | 24-17 |
| NCAAF | 2021/10/23 17:00 | Misericordia Cougars v Delaware Valley Aggies | L | 0-35 |
| NCAAF | 2021/10/16 16:00 | Stevenson Mustangs v Misericordia Cougars | L | 37-0 |
| NCAAF | 2021/10/09 17:00 | Lycoming Warriors v Misericordia Cougars | L | 44-16 |
| NCAAF | 2021/10/02 17:00 | Misericordia Cougars v Albright Lions | W | 31-20 |
| NCAAF | 2021/09/25 16:00 | Fdu Florham Devils v Misericordia Cougars | L | 31-20 |
| NCAAF | 2022/09/03 17:00 | Keystone Giants v Wilkes Colonels | L | 21-48 |
| NCAAF | 2021/11/06 17:00 | Suny Maritime Privateers v Keystone Giants | L | 24-21 |
| NCAAF | 2021/10/30 18:00 | Keystone Giants v Alfred State Pioneers | L | 7-38 |
| NCAAF | 2021/10/23 16:00 | Castleton Spartans v Keystone Giants | L | 41-0 |
| NCAAF | 2021/10/16 16:00 | Keystone Giants v Dean Bulldogs | L | 36-39 |
| NCAAF | 2021/10/09 16:00 | Gallaudet Bison v Keystone Giants | L | 34-14 |
| NCAAF | 2021/10/02 16:00 | Keystone Giants v Anna Maria Amcats | L | 35-55 |
| NCAAF | 2021/09/25 22:00 | Hobart Statesmen v Keystone Giants | L | 58-14 |