Stadium: otterbein memorial stadium Round: 1
| NCAAF | 2021/10/16 23:00 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-19 |
| NCAAF | 2019/10/19 23:00 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-35 |
| NCAAF | 2018/10/13 23:00 | Otterbein Cardinals v Heidelberg Student Princes | L | 7-21 |
| NCAAF | 2022/09/03 18:00 | Ohio Wesleyan Battling Bishops v Otterbein Cardinals | W | 13-21 |
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | L | 33-37 |
| NCAAF | 2021/11/06 17:30 | Marietta Pioneers v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2021/10/30 17:30 | Capital Crusaders v Otterbein Cardinals | W | 33-38 |
| NCAAF | 2021/10/23 18:00 | Otterbein Cardinals v Muskingum Muskies | L | 14-31 |
| NCAAF | 2021/10/16 23:00 | Heidelberg Student Princes v Otterbein Cardinals | L | 52-19 |
| NCAAF | 2021/10/02 17:30 | Mount Union v Otterbein Cardinals | L | 55-0 |
| NCAAF | 2021/09/25 17:30 | Ohio Northern Polar Bears v Otterbein Cardinals | L | 56-7 |
| NCAAF | 2022/09/03 23:00 | Heidelberg Student Princes v Adrian Bulldogs | W | 31-0 |
| NCAAF | 2021/11/13 18:30 | Ohio Northern Polar Bears v Heidelberg Student Princes | W | 32-33 |
| NCAAF | 2021/11/06 17:30 | Heidelberg Student Princes v John Carroll Blue Streaks | W | 27-21 |
| NCAAF | 2021/10/30 17:30 | Muskingum Muskies v Heidelberg Student Princes | W | 14-49 |
| NCAAF | 2021/10/23 17:30 | Heidelberg Student Princes v Mount Union | L | 14-49 |
| NCAAF | 2021/10/16 23:00 | Heidelberg Student Princes v Otterbein Cardinals | W | 52-19 |
| NCAAF | 2021/10/09 19:00 | Marietta Pioneers v Heidelberg Student Princes | W | 21-44 |
| NCAAF | 2021/09/25 17:30 | Baldwin Wallace Yellow Jackets v Heidelberg Student Princes | L | 20-10 |