Stadium: Bowditch Field Round: 1
| NCAAF | 2022/09/03 16:00 | Brockport Golden Eagles v Framingham State Rams | L | 27-7 |
| NCAAF | 2021/11/20 17:00 | Muhlenberg Mules v Framingham State Rams | L | 45-0 |
| NCAAF | 2021/11/13 17:00 | Worcester State Lancers v Framingham State Rams | W | 21-40 |
| NCAAF | 2021/11/06 16:00 | Framingham State Rams v Bridgewater State Bears | W | 47-13 |
| NCAAF | 2021/10/30 16:00 | Massachusetts Maritime Buccaneers v Framingham State Rams | W | 14-23 |
| NCAAF | 2021/10/09 19:00 | Fitchburg State Falcons v Framingham State Rams | W | 0-35 |
| NCAAF | 2021/10/02 17:00 | Plymouth State Panthers v Framingham State Rams | W | 0-33 |
| NCAAF | 2021/09/25 16:00 | Framingham State Rams v Westfield State Owls | W | 41-6 |
| NCAAF | 2022/09/03 17:00 | St John Fisher Cardinals v Buffalo State Bengals | W | 62-21 |
| NCAAF | 2021/11/13 18:00 | Utica Pioneers v St John Fisher Cardinals | L | 35-14 |
| NCAAF | 2021/11/06 17:00 | St John Fisher Cardinals v Cortland Red Dragons | L | 3-55 |
| NCAAF | 2021/10/30 18:30 | Hartwick Hawks v St John Fisher Cardinals | W | 7-28 |
| NCAAF | 2021/10/16 17:00 | St John Fisher Cardinals v Alfred Saxons | L | 35-38 |
| NCAAF | 2021/10/09 17:00 | Morrisville State Mustangs v St John Fisher Cardinals | W | 23-28 |
| NCAAF | 2021/10/02 22:00 | St John Fisher Cardinals v Brockport Golden Eagles | L | 7-34 |
| NCAAF | 2021/09/25 16:00 | Rpi Engineers v St John Fisher Cardinals | L | 41-7 |