Stadium: Mueller Field Round: 1
| NCAAF | 2021/09/09 23:00 | Wheeling Jesuit v Notre Dame Falcons | W | 15-31 |
| NCAAF | 2019/10/19 17:00 | Notre Dame Falcons v Wheeling Jesuit | W | 51-13 |
| NCAAF | 2022/09/01 22:00 | Ashland Eagles v Notre Dame Falcons | L | 31-14 |
| NCAAF | 2021/11/27 18:00 | Shepherd Rams v Notre Dame Falcons | L | 38-34 |
| NCAAF | 2021/11/20 17:00 | Notre Dame Falcons v Slippery Rock | W | 33-25 |
| NCAAF | 2021/11/13 17:00 | Notre Dame Falcons v Alderson Broaddus Battlers | W | 72-7 |
| NCAAF | 2021/11/06 16:00 | Unc Pembroke Braves v Notre Dame Falcons | W | 7-45 |
| NCAAF | 2021/10/30 16:00 | Notre Dame Falcons v Fairmont State | W | 45-0 |
| NCAAF | 2021/10/23 17:30 | Glenville State Pioneers v Notre Dame Falcons | W | 14-34 |
| NCAAF | 2021/10/16 17:00 | Notre Dame Falcons v W. Virginia Bobcats | W | 52-14 |
| NCAAF | 2022/09/01 23:00 | Wheeling Jesuit v Seton Hill Griffins | W | 25-11 |
| NCAAF | 2021/11/13 00:00 | Fairmont State v Wheeling Jesuit | L | 29-14 |
| NCAAF | 2021/11/06 16:00 | University of Charleston Golden Eagles v Wheeling Jesuit | L | 38-20 |
| NCAAF | 2021/10/30 16:00 | Wheeling Jesuit v Concord University Mountain Lions | W | 15-14 |
| NCAAF | 2021/10/23 17:00 | Wheeling Jesuit v West Liberty Hilltoppers | W | 26-20 |
| NCAAF | 2021/10/16 18:00 | Frostburg State v Wheeling Jesuit | L | 41-17 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling Jesuit | L | 34-28 |
| NCAAF | 2021/10/02 18:00 | Wheeling Jesuit v W. Virginia Bobcats | W | 38-0 |