| Guatemala Liga Nacional Women | 2022/08/28 19:00 | Club Deportivo Xela Women v Suchitepequez Women | W | 1-0 |
| Guatemala Liga Nacional Women | 2022/06/19 17:00 | Suchitepequez Women v Club Deportivo Xela Women | L | 4-3 |
| Guatemala Liga Nacional Women | 2022/06/05 16:30 | UNIFUT Antigua Women v Club Deportivo Xela Women | D | 1-1 |
| Guatemala Liga Nacional Women | 2022/05/22 19:00 | Club Deportivo Xela Women v FC Cremas Women | W | 3-1 |
| Guatemala Liga Nacional Women | 2022/04/24 19:00 | Club Deportivo Xela Women v Xinabajul Women | W | 4-0 |
| Guatemala Liga Nacional Women | 2022/03/27 19:00 | Club Deportivo Xela Women v Marquense Women | D | 0-0 |
| Guatemala Liga Nacional Women | 2022/03/06 19:00 | Club Deportivo Xela Women v Suchitepequez Women | D | 2-2 |
| Guatemala Liga Nacional Women | 2022/02/27 01:30 | Xinabajul Women v Club Deportivo Xela Women | D | 0-0 |
| Guatemala Liga Nacional Women | 2022/05/29 16:00 | Antigua GFC Women v Deportivo Mixco Women | L | 3-1 |
| Guatemala Liga Nacional Women | 2022/05/22 21:00 | Deportivo Mixco Women v Antigua GFC Women | L | 1-3 |
| Guatemala Liga Nacional Women | 2022/04/25 00:00 | Deportivo Mixco Women v Tunecas Women | D | 0-0 |
| Guatemala Liga Nacional Women | 2022/04/03 17:00 | Deportivo Mixco Women v K’iche FC Women | W | 1-0 |
| Guatemala Liga Nacional Women | 2022/03/27 21:00 | Antigua GFC Women v Deportivo Mixco Women | D | 2-2 |
| Guatemala Liga Nacional Women | 2022/03/06 17:00 | Tunecas Women v Deportivo Mixco Women | L | 3-1 |
| Guatemala Liga Nacional Women | 2022/02/27 02:00 | Deportivo Mixco Women v Deportivo Colomba Women | W | 3-0 |
| Guatemala Liga Nacional Women | 2022/02/20 01:00 | K’iche FC Women v Deportivo Mixco Women | L | 4-2 |