Stadium: James LaRosa Athletic Field Round: 1
| NCAAF | 2021/11/13 00:00 | Fairmont State v Wheeling Jesuit | L | 29-14 |
| NCAAF | 2021/11/06 16:00 | University of Charleston Golden Eagles v Wheeling Jesuit | L | 38-20 |
| NCAAF | 2021/10/30 16:00 | Wheeling Jesuit v Concord University Mountain Lions | W | 15-14 |
| NCAAF | 2021/10/23 17:00 | Wheeling Jesuit v West Liberty Hilltoppers | W | 26-20 |
| NCAAF | 2021/10/16 18:00 | Frostburg State v Wheeling Jesuit | L | 41-17 |
| NCAAF | 2021/10/09 16:00 | Unc Pembroke Braves v Wheeling Jesuit | L | 34-28 |
| NCAAF | 2021/10/02 18:00 | Wheeling Jesuit v W. Virginia Bobcats | W | 38-0 |
| NCAAF | 2021/09/25 16:00 | Glenville State Pioneers v Wheeling Jesuit | W | 10-27 |
| NCAAF | 2021/11/13 18:00 | Lock Haven v Seton Hill Griffins | W | 7-59 |
| NCAAF | 2021/11/06 16:00 | Seton Hill Griffins v Iup Crimson Hawks | L | 3-38 |
| NCAAF | 2021/10/30 20:00 | California Vulcans v Seton Hill Griffins | L | 42-14 |
| NCAAF | 2021/10/23 16:00 | Clarion Golden Eagles v Seton Hill Griffins | W | 0-49 |
| NCAAF | 2021/10/16 20:00 | Seton Hill Griffins v Gannon University Golden Knights | L | 10-14 |
| NCAAF | 2021/10/09 16:00 | Mercyhurst v Seton Hill Griffins | W | 17-19 |
| NCAAF | 2021/10/02 20:00 | Seton Hill Griffins v Edinboro | L | 7-17 |
| NCAAF | 2021/09/25 22:00 | Seton Hill Griffins v Slippery Rock | L | 17-41 |