Stadium: Hovey Field Round: 1
| NCAAF | 2021/11/06 18:00 | Virginia Union Panthers v Virginia State Trojans | W | 20-13 |
| NCAAF | 2021/10/30 17:00 | Elizabeth City State Vikings v Virginia Union Panthers | W | 14-44 |
| NCAAF | 2021/10/23 17:00 | Virginia Union Panthers v Bowie State Bulldogs | L | 7-27 |
| NCAAF | 2021/10/16 17:00 | Chowan Hawks v Virginia Union Panthers | W | 31-38 |
| NCAAF | 2021/10/09 17:00 | Virginia Union Panthers v Lincoln University | W | 32-0 |
| NCAAF | 2021/10/02 17:00 | Virginia Union Panthers v Shaw Bears | L | 7-27 |
| NCAAF | 2021/09/25 17:00 | Johnson C Smith GB v Virginia Union Panthers | W | 7-43 |
| NCAAF | 2021/09/18 22:00 | Virginia Union Panthers v Lynchburg Dragons | W | 49-7 |
| NCAAF | 2021/10/23 18:30 | Tennessee Tech v Lynchburg Dragons | L | 56-13 |
| NCAAF | 2021/10/16 18:00 | Norfolk State v Lynchburg Dragons | L | 42-14 |
| NCAAF | 2021/10/09 18:00 | Delaware State v Lynchburg Dragons | L | 56-6 |
| NCAAF | 2021/10/02 18:00 | Erskine Flying Fleet v Lynchburg Dragons | L | 59-13 |
| NCAAF | 2021/09/25 17:00 | Duquesne v Lynchburg Dragons | L | 56-7 |
| NCAAF | 2021/09/18 22:00 | Virginia Union Panthers v Lynchburg Dragons | L | 49-7 |
| NCAAF | 2021/09/09 23:00 | Mars Hill Lions v Lynchburg Dragons | L | 50-14 |
| NCAAF | 2021/09/04 16:00 | Virginia Wise Highland Cavaliers v Lynchburg Dragons | L | 54-0 |