Stadium: Knight Stadium Round: 1
| NCAAF | 2021/11/06 16:00 | Nc Wesleyan Battling Bishops v Southern Virginia Knights | L | 19-10 |
| NCAAF | 2021/10/30 17:00 | Southern Virginia Knights v Averett Cougars | L | 23-28 |
| NCAAF | 2021/10/23 17:00 | Brevard Tornados v Southern Virginia Knights | L | 7-3 |
| NCAAF | 2021/10/16 17:00 | Southern Virginia Knights v Greensboro Pride | W | 31-14 |
| NCAAF | 2021/10/09 17:00 | Southern Virginia Knights v Huntingdon Hawks | L | 20-48 |
| NCAAF | 2021/10/02 17:00 | Maryville Scots v Southern Virginia Knights | L | 38-17 |
| NCAAF | 2021/09/25 17:00 | Methodist Monarchs v Southern Virginia Knights | L | 37-14 |
| NCAAF | 2021/09/18 17:00 | Southern Virginia Knights v Lagrange Panthers | L | 34-38 |
| NCAAF | 2021/11/13 18:30 | Otterbein Cardinals v Wilmington Quakers | W | 33-37 |
| NCAAF | 2021/11/06 19:00 | Wilmington Quakers v Capital Crusaders | W | 24-21 |
| NCAAF | 2021/10/30 19:00 | John Carroll Blue Streaks v Wilmington Quakers | L | 50-7 |
| NCAAF | 2021/10/23 19:00 | Baldwin Wallace Yellow Jackets v Wilmington Quakers | L | 41-7 |
| NCAAF | 2021/10/16 19:00 | Wilmington Quakers v Marietta Pioneers | L | 7-35 |
| NCAAF | 2021/10/09 19:00 | Wilmington Quakers v Mount Union | L | 0-63 |
| NCAAF | 2021/09/25 17:30 | Muskingum Muskies v Wilmington Quakers | L | 62-14 |
| NCAAF | 2021/09/18 19:00 | Wilmington Quakers v Ohio Northern Polar Bears | L | 27-62 |