Stadium: Harvey Randall Wickes Memorial Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Michigan Technological University Huskies v Saginaw Valley State Cardinals | L | 21-20 |
| NCAAF | 2021/11/06 17:00 | Saginaw Valley State Cardinals v Northern Michigan Wildcats | W | 33-21 |
| NCAAF | 2021/10/30 16:00 | Davenport Panthers v Saginaw Valley State Cardinals | W | 3-24 |
| NCAAF | 2021/10/23 19:00 | Saginaw Valley State Cardinals v Wayne State Warriors Football | W | 41-25 |
| NCAAF | 2021/10/16 18:00 | Saginaw Valley State Cardinals v Northwood Timberwolves | W | 31-13 |
| NCAAF | 2021/10/09 21:00 | East Texas A&M v Saginaw Valley State Cardinals | W | 17-20 |
| NCAAF | 2021/10/02 18:00 | Saginaw Valley State Cardinals v Grand Valley State | L | 17-49 |
| NCAAF | 2021/09/25 22:00 | Wayne State Warriors Football v Saginaw Valley State Cardinals | W | 21-41 |
| NCAAF | 2021/11/13 18:00 | W. Virginia Bobcats v Glenville State Pioneers | L | 13-43 |
| NCAAF | 2021/11/06 17:00 | Frostburg State v W. Virginia Bobcats | L | 55-14 |
| NCAAF | 2021/10/28 23:00 | University of Charleston Golden Eagles v W. Virginia Bobcats | L | 45-6 |
| NCAAF | 2021/10/23 17:00 | W. Virginia Bobcats v Alderson Broaddus Battlers | L | 20-49 |
| NCAAF | 2021/10/16 17:00 | Notre Dame Falcons v W. Virginia Bobcats | L | 52-14 |
| NCAAF | 2021/10/09 17:30 | W. Virginia Bobcats v West Virginia State Yellow Jackets | L | 3-38 |
| NCAAF | 2021/10/02 18:00 | Wheeling v W. Virginia Bobcats | L | 38-0 |
| NCAAF | 2021/09/25 17:00 | W. Virginia Bobcats v West Liberty Hilltoppers | L | 0-31 |