Stadium: Allgood-Bailey Stadium Round: 1
| NCAAF | 2021/11/13 19:00 | Southwest Baptist University Bearcats v Missouri S&t Miners | W | 41-42 |
| NCAAF | 2021/11/06 18:00 | Missouri S&t Miners v Lindenwood | L | 16-43 |
| NCAAF | 2021/10/30 18:00 | Missouri S&t Miners v Indianapolis Greyhounds | W | 31-28 |
| NCAAF | 2021/10/23 18:00 | McKendree v Missouri S&t Miners | W | 31-37 |
| NCAAF | 2021/10/16 18:00 | Missouri S&t Miners v William Jewell College Cardinals | W | 37-16 |
| NCAAF | 2021/10/09 18:00 | Missouri S&t Miners v Truman Bulldogs | L | 21-38 |
| NCAAF | 2021/10/02 18:00 | Quincy v Missouri S&t Miners | L | 31-28 |
| NCAAF | 2021/09/25 20:00 | Hillsdale Chargers v Missouri S&t Miners | L | 38-31 |
| NCAAF | 2021/11/13 19:00 | South Dakota Mines Hardrockers v Colorado Mesa University Mavericks | L | 10-13 |
| NCAAF | 2021/11/06 18:00 | N. Mexico H. Cowboys v South Dakota Mines Hardrockers | W | 17-40 |
| NCAAF | 2021/10/30 19:00 | Black Hills State v South Dakota Mines Hardrockers | W | 10-13 |
| NCAAF | 2021/10/23 18:00 | South Dakota Mines Hardrockers v Western State Colorado Mountaineers | L | 21-42 |
| NCAAF | 2021/10/16 18:00 | Colorado School of Mines v South Dakota Mines Hardrockers | L | 44-24 |
| NCAAF | 2021/10/09 18:00 | South Dakota Mines Hardrockers v Fort Lewis Skyhawks | W | 42-7 |
| NCAAF | 2021/10/02 19:00 | Adams State Grizzlies v South Dakota Mines Hardrockers | W | 42-45 |
| NCAAF | 2021/09/25 22:00 | South Dakota Mines Hardrockers v Colorado State Pueblo Thunderwolves | L | 7-49 |