Stadium: Pioneer Field Round: 1
| NCAAF | 2021/11/13 18:30 | Tusculum Pioneers v Carson–Newman Eagles | W | 48-13 |
| NCAAF | 2021/11/06 17:00 | Mars Hill Lions v Tusculum Pioneers | L | 20-7 |
| NCAAF | 2021/10/30 17:00 | Catawba College v Tusculum Pioneers | L | 31-28 |
| NCAAF | 2021/10/23 18:00 | Tusculum Pioneers v Barton Bulldogs | W | 41-17 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | W | 37-21 |
| NCAAF | 2021/10/09 18:00 | Lenoir Rhyne Bears v Tusculum Pioneers | L | 38-31 |
| NCAAF | 2021/10/02 22:00 | Wingate Bulldogs v Tusculum Pioneers | L | 43-35 |
| NCAAF | 2021/09/25 17:30 | Tusculum Pioneers v Newberry Wolves | L | 19-24 |
| NCAAF | 2021/11/06 17:00 | St Augustines Falcons v Shaw Bears | W | 21-17 |
| NCAAF | 2021/10/30 17:00 | Johnson C Smith GB v St Augustines Falcons | L | 34-13 |
| NCAAF | 2021/10/23 17:00 | St Augustines Falcons v Fayetteville State Broncos | L | 12-40 |
| NCAAF | 2021/10/16 17:30 | Winston-Salem State v St Augustines Falcons | L | 41-0 |
| NCAAF | 2021/10/09 17:30 | Livingstone C. BB v St Augustines Falcons | L | 21-7 |
| NCAAF | 2021/10/02 22:00 | Virginia State Trojans v St Augustines Falcons | L | 33-9 |
| NCAAF | 2021/09/25 17:00 | St Augustines Falcons v Chowan Hawks | L | 12-59 |
| NCAAF | 2021/09/04 17:00 | St Augustines Falcons v Tusculum Pioneers | L | 14-58 |