Stadium: Garrison Stadium Round: 1
| NCAAF | 2021/11/06 17:00 | Chowan Hawks v Lincoln University Lions | W | 28-12 |
| NCAAF | 2021/10/30 18:00 | Virginia State Trojans v Chowan Hawks | W | 30-38 |
| NCAAF | 2021/10/23 17:30 | Elizabeth City State Vikings v Chowan Hawks | L | 32-28 |
| NCAAF | 2021/10/16 17:00 | Chowan Hawks v Virginia Union Panthers | L | 31-38 |
| NCAAF | 2021/10/09 17:00 | Chowan Hawks v Bowie State Bulldogs | L | 3-14 |
| NCAAF | 2021/10/02 22:00 | Chowan Hawks v Winston-Salem State | W | 73-7 |
| NCAAF | 2021/09/25 17:00 | St Augustines Falcons v Chowan Hawks | W | 12-59 |
| NCAAF | 2021/09/18 17:00 | Chowan Hawks v Erskine Flying Fleet | W | 49-19 |
| NCAAF | 2021/11/13 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | W | 24-36 |
| NCAAF | 2021/11/06 20:00 | Barton Bulldogs v Lenoir Rhyne Bears | L | 20-56 |
| NCAAF | 2021/10/30 18:00 | Barton Bulldogs v Bluefield College Rams | W | 62-7 |
| NCAAF | 2021/10/30 18:00 | Barton Bulldogs v Bluefield State | W | 62-7 |
| NCAAF | 2021/10/23 18:00 | Tusculum Pioneers v Barton Bulldogs | L | 41-17 |
| NCAAF | 2021/10/16 22:00 | Barton Bulldogs v Wingate Bulldogs | W | 26-20 |
| NCAAF | 2021/10/09 17:30 | Mars Hill Lions v Barton Bulldogs | L | 40-32 |
| NCAAF | 2021/10/02 18:00 | Barton Bulldogs v Carson–Newman Eagles | W | 31-17 |