Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2021/11/13 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 24-36 |
| NCAAF | 2021/11/06 17:00 | Catawba College v Virginia Wise Highland Cavaliers | W | 7-30 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |
| NCAAF | 2021/10/23 16:00 | Virginia Wise Highland Cavaliers v Wingate Bulldogs | L | 21-48 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | L | 37-21 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | L | 14-37 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |
| NCAAF | 2021/09/25 16:00 | Virginia Wise Highland Cavaliers v Carson–Newman Eagles | W | 33-7 |
| NCAAF | 2021/11/13 18:00 | Emory And Henry Wasps v Ferrum Panthers | L | 41-23 |
| NCAAF | 2021/11/06 17:00 | Washington And Lee Generals v Ferrum Panthers | L | 28-24 |
| NCAAF | 2021/10/30 18:00 | Ferrum Panthers v Guilford Quakers | W | 57-35 |
| NCAAF | 2021/10/23 17:00 | Hampden Sydney Tigers v Ferrum Panthers | L | 42-28 |
| NCAAF | 2021/10/16 17:00 | Ferrum Panthers v Shenandoah Hornets | W | 24-23 |
| NCAAF | 2021/10/09 18:00 | Bridgewater Eagles v Ferrum Panthers | W | 10-14 |
| NCAAF | 2021/10/02 17:00 | Ferrum Panthers v Randolph Macon Yellow Jackets | L | 21-44 |
| NCAAF | 2021/09/25 17:00 | Ferrum Panthers v The Apprentice School Builders | W | 30-28 |