Stadium: William H. Greene Stadium Round: 1
| NCAAF | 2021/09/03 00:00 | Colorado Mesa University Mavericks v William Jewell College Cardinals | L | 40-3 |
| NCAAF | 2021/11/13 19:00 | William Jewell College Cardinals v Quincy | L | 17-51 |
| NCAAF | 2021/11/06 18:00 | Indianapolis Greyhounds v William Jewell College Cardinals | L | 45-14 |
| NCAAF | 2021/10/30 18:00 | William Jewell College Cardinals v Lindenwood | L | 10-53 |
| NCAAF | 2021/10/23 19:00 | Truman Bulldogs v William Jewell College Cardinals | L | 52-0 |
| NCAAF | 2021/10/16 18:00 | Missouri S&t Miners v William Jewell College Cardinals | L | 37-16 |
| NCAAF | 2021/10/09 20:00 | William Jewell College Cardinals v Southwest Baptist University Bearcats | L | 10-55 |
| NCAAF | 2021/10/02 18:00 | McKendree v William Jewell College Cardinals | L | 52-10 |
| NCAAF | 2021/09/25 16:00 | Kentucky Wesleyan v William Jewell College Cardinals | L | 41-21 |
| NCAAF | 2021/11/13 19:00 | South Dakota Mines Hardrockers v Colorado Mesa University Mavericks | W | 10-13 |
| NCAAF | 2021/11/06 19:00 | Colorado Mesa University Mavericks v Black Hills State | W | 52-9 |
| NCAAF | 2021/10/30 19:00 | Western State Colorado Mountaineers v Colorado Mesa University Mavericks | L | 23-9 |
| NCAAF | 2021/10/23 19:00 | Colorado Mesa University Mavericks v Colorado School of Mines | W | 26-21 |
| NCAAF | 2021/10/16 18:00 | Fort Lewis Skyhawks v Colorado Mesa University Mavericks | W | 3-55 |
| NCAAF | 2021/10/10 00:00 | Colorado Mesa University Mavericks v Adams State Grizzlies | W | 49-14 |
| NCAAF | 2021/10/02 20:00 | Colorado State Pueblo Thunderwolves v Colorado Mesa University Mavericks | L | 19-13 |
| NCAAF | 2021/09/25 19:00 | Colorado Mesa University Mavericks v Chadron State Eagles | W | 24-17 |