Stadium: Scheels Field at MSUM Football Stadium Round: 1
| NCAAF | 2018/10/20 19:00 | Minnesota State University Moorhead Dragons v Sioux Falls Cougars | L | 21-55 |
| NCAAF | 2021/11/13 18:00 | Minnesota State University Moorhead Dragons v Wayne State Wildcats | L | 21-24 |
| NCAAF | 2021/11/06 17:00 | Concordia University Golden Bears v Minnesota State University Moorhead Dragons | W | 3-24 |
| NCAAF | 2021/10/30 17:00 | Minnesota State University Moorhead Dragons v Northern State Wolves | L | 27-33 |
| NCAAF | 2021/10/23 17:00 | Minnesota State University Moorhead Dragons v University of Mary Marauders | W | 35-31 |
| NCAAF | 2021/10/16 18:00 | Bemidji State Beavers v Minnesota State University Moorhead Dragons | L | 22-19 |
| NCAAF | 2021/10/09 19:00 | Minot State Beavers v Minnesota State University Moorhead Dragons | W | 17-29 |
| NCAAF | 2021/10/02 17:00 | Minnesota State University Moorhead Dragons v Minnesota Duluth Bulldogs | L | 21-26 |
| NCAAF | 2021/09/25 17:00 | Minnesota State University Moorhead Dragons v Upper Iowa | W | 33-28 |
| NCAAF | 2021/11/13 19:00 | Sioux Falls Cougars v Upper Iowa | W | 42-21 |
| NCAAF | 2021/11/06 18:00 | Wayne State Wildcats v Sioux Falls Cougars | W | 17-38 |
| NCAAF | 2021/10/30 18:00 | Minnesota State Mankato Mavericks v Sioux Falls Cougars | W | 35-45 |
| NCAAF | 2021/10/23 18:00 | Sioux Falls Cougars v Winona State Warriors | L | 10-14 |
| NCAAF | 2021/10/16 18:00 | Sioux Falls Cougars v University of Mary Marauders | W | 34-14 |
| NCAAF | 2021/10/09 22:00 | Southwest Minnesota State Mustangs v Sioux Falls Cougars | W | 7-35 |
| NCAAF | 2021/10/02 18:00 | Sioux Falls Cougars v Augustana Vikings | W | 28-26 |
| NCAAF | 2021/09/25 23:00 | Northern State Wolves v Sioux Falls Cougars | L | 41-10 |