Stadium: Norris Filed Round: 1
| NCAAF | 2021/09/04 23:00 | Harding Bisons v East Central Tigers | L | 28-0 |
| NCAAF | 2019/11/02 19:00 | Harding Bisons v East Central Tigers | L | 56-20 |
| NCAAF | 2018/10/27 21:00 | East Central Tigers v Harding Bisons | L | 7-49 |
| NCAAF | 2021/11/13 20:00 | Southeastern Oklahoma State Savage Storm v East Central Tigers | W | 28-30 |
| NCAAF | 2021/11/06 19:00 | Arkansas Monticello Boll Weevils v East Central Tigers | W | 10-35 |
| NCAAF | 2021/10/30 19:00 | East Central Tigers v Ouachita Baptist Tigers | L | 28-43 |
| NCAAF | 2021/10/23 19:00 | Southwestern Oklahoma State Bulldogs v East Central Tigers | W | 34-44 |
| NCAAF | 2021/10/16 23:00 | East Central Tigers v Oklahoma Baptist Bison | L | 20-47 |
| NCAAF | 2021/10/09 19:00 | Henderson State Reddies v East Central Tigers | L | 59-24 |
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | W | 38-17 |
| NCAAF | 2021/09/25 23:00 | Northwestern Oklahoma State Rangers v East Central Tigers | W | 17-20 |
| NCAAF | 2021/11/27 19:00 | Harding Bisons v NW Missouri State | L | 9-28 |
| NCAAF | 2021/11/20 19:00 | Harding Bisons v Washburn Ichabods Football | W | 30-14 |
| NCAAF | 2021/11/13 20:00 | Arkansas Tech Wonder Boys v Harding Bisons | W | 0-31 |
| NCAAF | 2021/11/06 19:00 | Southwestern Oklahoma State Bulldogs v Harding Bisons | W | 7-55 |
| NCAAF | 2021/10/30 19:00 | Northwestern Oklahoma State Rangers v Harding Bisons | W | 14-73 |
| NCAAF | 2021/10/23 20:00 | Harding Bisons v Arkansas Monticello Boll Weevils | W | 64-7 |
| NCAAF | 2021/10/16 19:00 | Henderson State Reddies v Harding Bisons | W | 21-46 |
| NCAAF | 2021/10/09 19:00 | Harding Bisons v Southern Nazarene | W | 49-10 |