Stadium: Wilkins Stadium Round: 1
| NCAAF | 2021/09/02 23:00 | Northwestern Oklahoma State Rangers v Southern Arkansas Muleriders | W | 13-32 |
| NCAAF | 2019/10/12 18:00 | Northwestern Oklahoma State Rangers v Southern Arkansas Muleriders | W | 7-40 |
| NCAAF | 2018/09/22 23:00 | Southern Arkansas Muleriders v Northwestern Oklahoma State Rangers | W | 27-14 |
| NCAAF | 2021/11/13 20:00 | Southern Arkansas Muleriders v Arkansas Monticello Boll Weevils | L | 37-73 |
| NCAAF | 2021/11/06 18:00 | Southern Nazarene v Southern Arkansas Muleriders | W | 10-31 |
| NCAAF | 2021/10/30 19:00 | Southern Arkansas Muleriders v Oklahoma Baptist Bison | L | 40-44 |
| NCAAF | 2021/10/23 18:00 | Ouachita Baptist Tigers v Southern Arkansas Muleriders | L | 42-7 |
| NCAAF | 2021/10/16 19:00 | Arkansas Tech Wonder Boys v Southern Arkansas Muleriders | W | 17-34 |
| NCAAF | 2021/10/09 19:30 | Southern Arkansas Muleriders v Southeastern Oklahoma State Savage Storm | L | 24-38 |
| NCAAF | 2021/10/02 19:00 | East Central Tigers v Southern Arkansas Muleriders | L | 38-17 |
| NCAAF | 2021/09/25 23:00 | Henderson State Reddies v Southern Arkansas Muleriders | L | 56-49 |
| NCAAF | 2021/11/13 21:00 | Northwestern Oklahoma State Rangers v Southwestern Oklahoma State Bulldogs | W | 31-28 |
| NCAAF | 2021/11/06 19:00 | Arkansas Tech Wonder Boys v Northwestern Oklahoma State Rangers | L | 56-21 |
| NCAAF | 2021/10/30 19:00 | Northwestern Oklahoma State Rangers v Harding Bisons | L | 14-73 |
| NCAAF | 2021/10/23 20:00 | Northwestern Oklahoma State Rangers v Southern Nazarene | W | 47-27 |
| NCAAF | 2021/10/16 19:00 | Southeastern Oklahoma State Savage Storm v Northwestern Oklahoma State Rangers | L | 43-10 |
| NCAAF | 2021/10/09 21:00 | Northwestern Oklahoma State Rangers v Arkansas Monticello Boll Weevils | L | 23-42 |
| NCAAF | 2021/10/02 17:00 | Ouachita Baptist Tigers v Northwestern Oklahoma State Rangers | L | 64-17 |
| NCAAF | 2021/09/25 23:00 | Northwestern Oklahoma State Rangers v East Central Tigers | L | 17-20 |